verb To give up as beyond hope or expectation; to despair of.
verb To cause to despair.
verb To be hopeless; to have no hope; to give up all hope or expectation. .mw-parser-output .object-usage-tag{font-style:italic}.mw-parser-output .deprecated{color:var(--wikt-palette-grey-lime-8,olivedrab)}[ with of]
noun Loss of hope; utter hopelessness; complete despondency.
He turned around in despair, aware that he was not going to survive.
noun That which causes despair.
noun That which is despaired of. (Can we add an example for this sense?)