agonize

About 0.11 uses per million words.

Meaning

1. verb To writhe with agony; to suffer violent anguish.
2. verb To struggle; to wrestle; to strive desperately, whether mentally or physically.
3. verb To cause agony or anguish in someone.
4. verb To act as an agonist upon; to combine with a receptor on a cell to produce a physiological reaction.

Similar words

agonise wring writhe throe wrench angst gripe wrangle twinge agrise

Often followed by

over about in for and with the to at

Word family

agonized agonizes agonizing